Ensrud, in Marcus and Feldman's Osteoporosis (Fifth Edition), 2021 17.3.3.2 Retrospective cohort studyĪ retrospective cohort study (e.g., historical cohort study) differs from a prospective one in that the assembly of the study cohort, baseline measurements, and follow-up have all occurred in the past. This was one of the few studies that determined the lowest threshold dose of hCG to maintain high pregnancy rates while decreasing risk of OHSS.
The incidence of moderate to severe OHSS was 0.13% ( n = 14) and severe OHSS was 0.03% ( n = 4) of cycles. Īnother retrospective cohort study at an academic medical center evaluated pregnancy outcomes and OHSS using a sliding scale hCG protocol in 10 427 fresh in vitro fertilization-intracytoplasmic sperm injections. Both medications were comparable in terms of clinical pregnancy and OHSS rates as compared to placebo. Both patients were 4000 pg/mL, and > 25 oocytes collected.
One mild case of OHSS occurred in both the leuprolide and triptorelin treatment groups in which both patients complained of lower abdominal pain, mild nausea, enlarged ovaries, and vomiting. Gibson, Amulya Tatachar, in Side Effects of Drugs Annual, 2018 Ovarian Hyperstimulation SyndromeĪ retrospective, cohort study assessed the efficacy of two different gonadotropin-releasing hormone (GnRH) agonists, triptorelin and leuprolide, in final oocyte maturation in patients with increased risk of ovarian hyperstimulation syndrome (OHSS).
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